Dr Jayakrupakar Nallala
Telephone: 01392 724149
Extension: (Streatham) 4149
My research interests are to develop novel approaches for clinical diagnosis and prognosis of cancers (breast, colon, oesophagus, head and neck, skin) and other molecular diseases (Alzheimer's disease). For this, I am working at the forefront of cross disciplines by combining novel spectroscopic, molecular imaging technologies and machine learning approaches (conventional and High Power Computing) with clinical practices of histopathology, immunohistochemistry, etc, to investigate molecular changes in cells, tissue and biofluids.
I am a Research Fellow in the £20M multinational Cancer Grand Challenge 'PRECISION' (https://www.dcisprecision.org/) project funded by the CRUK in which my main aim is to identify prognostic biomarkers of ductal carcinoma insitu (DCIS), which is a precursor to invasive breast cancer. Currently, it is not known as to which women diagnosed with DCIS develop an invasive breast cancer and which women remain with DCIS without developing an invasive cancer. Because of this uncertain progression, all women diagnosed with DCIS are given a treatment (surgery, radiation therapy and chemotherapy) which in most cases might not be needed. To avoid the unnecessary 'overtreatment of DCIS', I am specifically investigating the molecular and physico-chemical features of breast tissue and breast microcalfications. On a large cohort of tissue samples, I am using a combination of vibrational spectroscopy imaging techniques, X-ray diffraction and novel data mining tools and corroborating imaging features to genetic data from the same patients to identify biomarkers of DCIS progression.
1. I was a post-doctoral Research Fellow in the MINERVA project (http://minerva-project.eu/) funded by the European Union (FP7), in which I demonstrated a novel high-volume pathology screening approach for improved cancer diagnostics. I used a new generation infrared spectroscopic imaging based on spectral histopathology/cytology. I engaged with multi-national collaborations by bringing together concepts from optics, photonics, data mining tools, digital pathology and conventional clinical histopathology and immunohistochemistry.
2. I obtained my PhD from the Université de Reims Champagne-Ardenne, France during which the potentials of vibrational spectroscopy as a cancer diagnostic tool were demonstrated via the concepts of spectral histopathology and infrared spectral barcoding in clinical colon tissue and tissue arrays.
3. My initial research activities at CCMB and ACTREC, India involved DNA sequencing and genotyping of single nucleotide and repeat length polymorphisms in specific genes and their association with breast, and head and neck cancers.
Education and Research Activities
2018-Ongoing Post-doctoral Research Fellow, University of Exeter, United Kingdom (CRUK Cancer Grand Challenge-PRECISION)
2013-2017 Post-doc, University of Exeter, United Kingdom (MINERVA, EU FP7)
2009-2012 PhD, Université de Reims Champagne-Ardenne, France
2006-2008 Research Associate, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Mumbai, India
2005-2006 MSc Dissertation, Centre for Cellular and Molecular Biology (CCMB), Hyderabad, India
2004-2006 MSc Biotechnology, Bharathidasan University, Trichy, India
1999-2004 BSc Biotechnology (Distinction), Osmania University, Hyderabad, India
Funded Research Projects/Grants
1. Co-Investigator: EPSRC CLIRPath-AI Pump-Prime Award, September 2022, £50,000
2. Principal Investigator: Wellcome Trust ISSF Translational Research Exchange Pump-Prime Award (WT105618MA), August 2022, £40,000
3. Principal Investigator: Wellcome Trust ISSF Seed-Corn Fund Round 5, April 2018, £10,000
4. International travel grant from EPSRC CLIRPath-AI, April 2023, £2500
5. International travel grant from the Royal Society of Chemistry (RSC), September 2015, £800
6. Co-Investigator: Researcher-Led Initiative grant '‘Negative results: not junk, but an opportunity to learn'’ funded by the University of Exeter Researcher Development and Research Culture team, 2018, £1000
1. Invited speaker at SciX 2019, the annual meeting of the Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), October 13-18, Palm Springs, California, USA
2. Invited speaker at the Rajiv Gandhi University of Knowledge Technologies-RGUKT Basar (IIIT), January 3rd 2017, Telangana, India
3. Invited speaker at SciX 2016, the annual meeting of the Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), September 18-23, Minneapolis, USA
4. Invited speaker at the GW4 Imaging Network Sandpit Event, 22nd January 2015, Exeter, UK
5. Invited speaker at the International Conference on Optical, Optoelectronic and Photonic Materials (ICOOPMA), 27th July-1st August 2014, Leeds, UK
Awards and Recognitions
1. Invited principal author themed “Prominent Young Spectroscopists” for the special issue of the journal Vibrational Spectroscopy, 2015
2. ‘Rambhau Kulkarni Young Scientist Award’ from the Indian Association for Cancer Research (IACR), February, 2008, Ahmedabad, India
1. American Assication for Cancer Research (AACR), USA - Associate member
2. The International Society for Clinial Spectroscopy (CLIRSPEC) - Member
National/Regional Facility User:
1. User-Diamond Synchrotron Infrared Beamline, United Kingdom (B22: Multimode Infrared Imaging and Microspectroscopy Beamline (MIRIAM)
2. User-Diamond Synchrotron X-ray micro-diffraction beamline, United Kingdom (I18: Microfocus Spectroscopy)
3. User-CONTRAST Facility, Exeter. The UK Healthcare Coherent Raman Scattering facility
3. User-ISCA: Advanced High Power Computing (HPC), University of Exeter (https://www.exeter.ac.uk/researchcomputing/e-infrastructure/)
Other Professional Contributions:
Journal Board of Reviewers for 'Cancers'
Reviewer for international scientific journals: PLoS ONE, Journal of Raman Spectroscopy, Sensors, Biosensors, Molecules