Physics and Astronomy

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Prof Nick Stone

Professor of Biomedical Imaging and Biosensing

 N.Stone@exeter.ac.uk

 (Streatham) 6531

 01392 726531

Overview

Professor Nicholas Stone (h index = 52), Professor of Biomedical Imaging and Biosensing, School of Physics and Astronomy, University of Exeter is also an HCPC registered [CS3557] Consultant Clinical Scientist (Medical Physics), holding positions in two leading NHS Foundation Hospital Trusts. He recently led the School of Physics and Astronomy at the University of Exeter 2015-2018. Prior to that he was Director of Research. 

Nick is the University Lead for Healthcare Technologies' and has a strong track record working at the interface between physics, engineering and medicine. In 2012 he was appointed to the position of Professor of Biomedical Imaging and Biosensing at the University of Exeter, leading him to relinquish the positions of Consultant Clinical Scientist and Head of the Biophotonics Research Unit at Gloucestershire Hospitals and Professor of Biophotonics at Cranfield University. There he established an internationally recognised research unit within a district general hospital pioneering novel optical techniques for diagnostics and therapeutics. He built this unit from scratch and succeeded in funding it in its entirety for 13-14 years. 

He has International recognition as a leader in the field of biomedical vibrational spectroscopy for diagnostics. He was awarded Institute of Physics and Engineering in Medicine Acaxdemic Gold Medal (2020) and the Chief Scientific Officer’s National R&D Award for 2009, the ICORS - International Raman award in 2014 and various other national and international prizes. He have published 7 book chapters; over 200 peer reviewed papers and proceedings and 7 patents. He has been an invited speaker at over 60 national and international conferences and chaired and organised leading events in the field (SPEC 2008, 2010, 2012; FACSS Bioanalytical Section; Numerous IPEM Medical Physics Conferences; BMLA National and European Conferences; SPIE Conferences; Rank Prize).  

Prof Stone has raised over £20 million grant income and led numerous projects to explore novel diagnostics and therapeutics utilising the power of light. He currently holds grants from the EPSRC, NIHR, MRC and CRUK of around £11.5M, covering fundamental science to clinical translation, with most being large scale multi-institutional and cross-disciplinary. NS’ current EPSRC grants exceed £8M as PI [EP/R020965/1 & EP/P012442/1] and Co-I [EP/S009957/1 & NS/A000063/1] and he is a holder of one of only a handful of EPSRC Health Technologies (HT) Programme and Strategic Equipment grants. 

Prof Stone has worked in a national leadership role in Medical Physics (Director of Science, Institute of Physics and Engineering in Medicine (2009-2011); Vice President and Chair of Academic Advisory Group to Council (2011-2014)) and has sat on the board of various societies: the Institute of Physics in Medicine and Biology, British Medical Laser Association, the Head and Neck Optical Diagnostics Society. Recently as a Founder Director I helped to form the International Society of Clinical Spectroscopy (CLIRSPEC). He holds fellowships (FRSC, FIPEM, FSAS) from 3 international learned societies.

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Publications

Copyright Notice: Any articles made available for download are for personal use only. Any other use requires prior permission of the author and the copyright holder.

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2023

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

  • Kerssens MM. (2012) Study of calcification formation and disease diagnostics utilising advanced vibrational spectroscopy.
  • Carey D, Shepherd N, Kendall C, Stone N, Breckon T. (2012) Visualising and grading the continuity of epithelial structures of colonic polyps, PERCEPTION, volume 41, pages 367-368.
  • Horsnell J. (2012) The use of Raman spectroscopy for the intra-operative assessment of axillary lymph nodes in breast cancer.
  • Carey D, Shepherd N, Kendall C, Stone N, Breckon TP, Lloyd GR. (2012) Correlating histology and spectroscopy to differentiate pathologies of the colon.
  • Xie H-N, Stevenson R, Stone N, Hernandez-Santana A, Faulds K, Graham D. (2012) Tracking Bisphosphonates through a 20 mm Thick Porcine Tissue by Using Surface-Enhanced Spatially Offset Raman Spectroscopy, Angewandte Chemie, volume 124, pages 8637-8639, article no. 34.
  • Almond M, Hutchings J, Kendall C, Stone N, Shepherd N, Barr H. (2012) PTU-198 Towards objective endoscopic diagnosis of early Barrett’s neoplasia using fibre-optic Raman spectroscopy, Gut, volume 61, pages A266-A266, article no. Suppl 2.
  • Horsnell J, Kallaway C, Chan C, Bristol J, Court F, Stone N. (2012) 420 Real Time Assessment of Axillary Nodes Based On Molecular Differences Using Raman Spectroscopy, European Journal of Cancer, volume 48, pages S169-S169.
  • Matousek P, Parker AW, Stone N. (2012) Raman analysis of tissue and/or calcifications.
  • Horsnell J, Kallaway C, Chan C, Bristol J, Court F, Stone N. (2012) Real Time Assessment of Axillary Nodes Based On Molecular Differences Using Raman Spectroscopy, EUROPEAN JOURNAL OF CANCER, volume 48, pages S169-S169. [PDF]
  • Horsnell J, Kallaway C, Chan C, Bristol J, Stone N. (2012) The role of Raman spectroscopy in the intraoperative assessment of axillary lymph nodes in breast cancer, BRITISH JOURNAL OF SURGERY, volume 99, pages 5-6. [PDF]
  • Almond M, Hutchings J, Kendall C, Stone N, Shepherd N, Barr H. (2012) TOWARDS OBJECTIVE ENDOSCOPIC DIAGNOSIS OF EARLY BARRETT'S NEOPLASIA USING FIBRE-OPTIC RAMAN SPECTROSCOPY, GUT, volume 61, pages A266-A266, DOI:10.1136/gutjnl-2012-302514c.198. [PDF]
  • Almond LM, Hutchings J, Kendall C, Day JCC, Stevens OAC, Lloyd GR, Shepherd NA, Barr H, Stone N. (2012) Assessment of a custom-built Raman spectroscopic probe for diagnosis of early oesophageal neoplasia, JOURNAL OF BIOMEDICAL OPTICS, volume 17, no. 8, article no. ARTN 081421, DOI:10.1117/1.JBO.17.8.081421. [PDF]
  • Xie HN, Stevenson R, Stone N, Hernandez-Santana A, Faulds K, Graham D. (2012) Tracking bisphosphonates through a 20 mm thick porcine tissue by using surface-enhanced spatially offset raman spectroscopy, Angewandte Chemie - International Edition, volume 51, no. 34, pages 8509-8511, DOI:10.1002/anie.201203728.
  • Almond LM, Hutchings J, Lloyd GR, Francis-Jones J, Stone N, Barr H, Kendall C. (2012) Preclinical evaluation of a Raman spectroscopic probe for endoscopic classification of oesophageal pathologies, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, volume 8219, DOI:10.1117/12.919876.
  • Lloyd GR, Hutchings J, Almond LM, Barr H, Kendall C, Stone N. (2012) Assessing the performance of spectroscopic models for cancer diagnostics using cross-validation and permutation testing, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, volume 8219, DOI:10.1117/12.919864.
  • Lloyd GR, Wood J, Kendall C, Cook T, Shepherd N, Stone N. (2012) Histological imaging of a human colon polyp sample using Raman spectroscopy and self organising maps, Vibrational Spectroscopy.
  • Lloyd GR, Wood J, Kendall C, Cook T, Shepherd N, Stone N. (2012) Histological imaging of a human colon polyp sample using Raman spectroscopy and self organising maps, Vibrational Spectroscopy, volume 60, pages 43-49, DOI:10.1016/j.vibspec.2012.02.015.
  • Horsnell JD, Smith JA, Sattlecker M, Sammon A, Christie-Brown J, Kendall C, Stone N. (2012) Raman spectroscopy--a potential new method for the intra-operative assessment of axillary lymph nodes, Surgeon, volume 10, no. 3, pages 123-127, DOI:10.1016/j.surge.2011.02.004. [PDF]

2011

2010

2009

2008

2007

2006

  • Stone N, Kaiser K, White RD. (2006) Autotuning of a pid controller for an active vibration suppression device for the treatment of essential tremor, American Society of Mechanical Engineers, Dynamic Systems and Control Division (Publication) DSC, DOI:10.1115/IMECE2006-14138.
  • Stone N, Prieto MCH, Kendall CA, Shetty G, Barr H. (2006) Raman spectroscopic biochemical mapping of tissues [6093-29], PROCEEDINGS-SPIE THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, volume 6093, pages 60930U-60930U.
  • Subramanian K, Stone N, Kendall C, Brown JC, McCarthy K, Bristol J, Chan YH. (2006) Infrared spectroscopy: a novel tool to aid classification of DCIS [6093-18], PROCEEDINGS-SPIE THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, volume 6093, pages 60930J-60930J.
  • Baker RN, Smith J, Rogers KD, Stone N. (2006) Vibrational spectroscopic analysis of breast calcifications and surrounding tissue [6093-32], PROCEEDINGS-SPIE THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, volume 6093, pages 60930X-60930X.
  • Sherry G, Kendall C, Shephard N, Stone N, Barr H. (2006) Novel technique in understanding the sequence of biochemical changes in carcinogenesis of esophagus, GASTROENTEROLOGY, volume 130, pages A311-A311.
  • Das K, Stone N, Kendall C, Fowler C, Christie-Brown J. (2006) Fourier transform infrared spectroscopy (FTIR) of parathyroid pathology.
  • Grimbergen MCM, van Swol CFP, van Moorselaar RJA, Stone N, others. (2006) Feasibility of Raman spectroscopy in vitro after 5-ALA-based fluorescence diagnosis in the bladder, Biomedical Optics 2006, pages 60781D-60781D.
  • Taylor JC, Kendall CA, Shepherd NA, Stone N, Cook TA. (2006) Raman spectroscopic mapping to evaluate the biochemical changes associated with the development of colorectal neoplasia, GUT, volume 55, pages A85-A85. [PDF]
  • Subramanian K, Kendall C, Stone N, Brown JC, McCarthy K, Bristol J, Chan YH. (2006) Raman spectroscopic analysis of atypical proliferative lesions of the breast, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, volume 6088, DOI:10.1117/12.644553.
  • Barr H, Kendall C, Bazant-Hegemark F, Stone N. (2006) Endoscopic photodynamic therapy for oesophageal disease, Photodiagnosis and Photodynamic Therapy, volume 3, no. 2, pages 102-105, DOI:10.1016/j.pdpdt.2006.03.008.
  • Stone N, Prieto MCH, Kendall CA, Shetty G, Barr H. (2006) Raman spectroscopic biochemical mapping of tissues, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, volume 6093, DOI:10.1117/12.644178.
  • Baker RN, Smith J, Rogers KD, Stone N. (2006) Vibrational spectroscopic analysis of breast calcifications and surrounding tissue, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, volume 6093, DOI:10.1117/12.644497.
  • Subramanian K, Stone N, Kendall C, Brown JC, McCarthy K, Bristol J, Chan YH. (2006) Infrared spectroscopy a novel tool to aid classification of DCIS, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, volume 6093, DOI:10.1117/12.644512.
  • Sowa MG, Smith MSD, Kendall C, Bock ER, Alex CTKO, Choo-Smith LPI, Stone N. (2006) Semi-parametric estimation in the compositional modeling of multicomponent systems from Raman spectroscopic data, Applied Spectroscopy, volume 60, no. 8, pages 877-883, DOI:10.1366/000370206778062147.
  • Das K, Stone N, Kendall C, Fowler C, Christie-Brown J. (2006) Raman spectroscopy of parathyroid tissue pathology, Lasers Med Sci, volume 21, no. 4, pages 192-197, DOI:10.1007/s10103-006-0397-7. [PDF]
  • Barr H, Kendall C, Bazant-Hegemark F, Moayyedi P, Shetty G, Stone N. (2006) Endoscopic screening and surveillance for Barrett's esophagus--clinical implications, MedGenMed, volume 8, no. 2. [PDF]
  • Barr H, Kendall C, Bazant-Hegemark F, Moayyedi P, Shetty G, Stone N. (2006) Endoscopic screening and surveillance for Barrett's esophagus--clinical implications, MedGenMed, volume 8, no. 2. [PDF]
  • Shetty G, Kendall C, Shepherd N, Stone N, Barr H. (2006) Raman spectroscopy: elucidation of biochemical changes in carcinogenesis of oesophagus, Br J Cancer, volume 94, no. 10, pages 1460-1464, DOI:10.1038/sj.bjc.6603102. [PDF]

2005

  • Smith J, Kendall C, Sammon AM, Christie-Brown J, Mandalia T, Stone N. (2005) Raman Spectroscopy is Sensitive and Specific in the Detection of Lymph Node Metastases in Breast Cancer, Diagnostic Optical Spectroscopy in Biomedicine III, DOI:10.1364/ecbo.2005.tuc2.
  • Smith J, Kendall C, Sammon AM, Christie-Brown J, Mandalia T, Stone N. (2005) Raman spectroscopy is sensitive and specific in the detection of lymph node metastases in breast cancer [5862-02], PROCEEDINGS-SPIE THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, volume 5862, pages 586202-586202.
  • Shetty G, Kendall C, Shepherd N, Stone N, Barr H. (2005) Biochemical mapping of esophageal carcinogenesis with Raman spectroscopy, GASTROENTEROLOGY, volume 128, pages A252-A252.
  • Van Swol C, Grimbergen M, Van Moorselaar R, Stone N, others. (2005) Feasibility of Raman Spectroscopy after 5-ALA Based Fluorescence Diagnosis in the Bladder, Australasian Physical & Engineering Sciences in Medicine, volume 28, pages 300-300, article no. 4.
  • Fitzmaurice M, Haka AA, Volynskaya Z, Motz JT, Gardecki JA, Nazemi J, Wang N, Klein N, Shenk R, Woletz J. (2005) Raman spectroscopy: development of clinical applications for breast cancer diagnosis, European Conference on Biomedical Optics 2005, pages 586201-586201.
  • Consuelo M, Prieto H, Matousek P, Towrie M, Parker AW, Wright M, Ritchie AW, Stone N. (2005) Use of picosecond Kerr-gated Raman spectroscopy to suppress signals from both surface and deep layers in bladder and prostate tissue, Journal of Biomedical Optics, volume 10, pages 044006-1, article no. 4.
  • GEETA S, Kendall C, Warren B, Geboes K, Shepherd N, Stone N, Barr H. (2005) Potential endoscopic technique for early diagnosis of Barrett’s malignancy-Raman spectroscopy, Gastroenterology, volume 128, pages A90-A90.
  • Smith J, Kendall C, Sammon AM, Christie-Brown J, Mandalia T, Stone N. (2005) Raman spectroscopy is sensitive and specific in the detection of lymph node metastases in breast cancer, Optics InfoBase Conference Papers.
  • Prieto MCH, Wright M, Ritchie AW, Stone N. (2005) The use of Raman spectroscopy to determine the biochemical basis to pathologies within the prostate, BJU INTERNATIONAL, volume 95, pages 17-17. [PDF]
  • Smith J, Kendall C, Christie-Brown J, Chan C, Sammon A, Barr H, Stone N. (2005) Raman spectroscopy is a sensitive, specific and rapid technique for the assessment of lymph node metastases in breast carcinoma, BRITISH JOURNAL OF SURGERY, volume 92, pages 70-70. [PDF]
  • Shetty G, Kendall C, Warren B, Geboes K, Shepherd N, Stone N, Barr H. (2005) Raman spectroscopy: Illumination of biochemical changes in carcinogenesis with potential endoscopic application, GUT, volume 54, pages A51-A51. [PDF]
  • Prieto MCH, Wright M, Ritchie AW, Stone N. (2005) The use of Raman spectroscopy to determine the biochemical basis to pathologies within the bladder, BJU INTERNATIONAL, volume 95, pages 21-21. [PDF]
  • Smith J, Kendall C, Christie-Brown J, Sammon A, Barr H, Stone N. (2005) Optical assessment of axillary lymph nodes in breast carcinoma, BREAST CANCER RESEARCH AND TREATMENT, volume 94, pages S42-S43. [PDF]
  • Goyal A, Hart-Prieto C, Stone N, Chopra M, Cooper A. (2005) Using Raman microspectroscopy to detect lycopene uptake into prostate cancer cells in vitro, PROCEEDINGS OF THE NUTRITION SOCIETY, volume 64, pages 71A-71A. [PDF]
  • Reyes-Goddard JM, Barr H, Stone N. (2005) Photodiagnosis using Raman and surface enhanced Raman scattering of bodily fluids, Photodiagnosis and Photodynamic Therapy, volume 2, no. 3, pages 223-233, DOI:10.1016/S1572-1000(05)00066-9.
  • Smith J, Kendall C, Sammon AM, Christie-Brown J, Mandalia T, Stone N. (2005) Raman spectroscopy is sensitive and specific in the detection of lymph node metastases in breast cancer, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, volume 5862, pages 1-7.
  • Prieto MCH, Matousek P, Towrie M, Parker AW, Wright M, Ritchie AW, Stone N. (2005) Use of picosecond Kerr-gated Raman spectroscopy to suppress signals from both surface and deep layers in bladder and prostate tissue, J Biomed Opt, volume 10, no. 4, DOI:10.1117/1.1991848. [PDF]
  • Crow P, Barrass B, Kendall C, Hart-Prieto M, Wright M, Persad R, Stone N. (2005) The use of Raman spectroscopy to differentiate between different prostatic adenocarcinoma cell lines, Br J Cancer, volume 92, no. 12, pages 2166-2170, DOI:10.1038/sj.bjc.6602638. [PDF]
  • Crow P, Molckovsky A, Stone N, Uff J, Wilson B, WongKeeSong L-M. (2005) Assessment of fiberoptic near-infrared raman spectroscopy for diagnosis of bladder and prostate cancer, Urology, volume 65, no. 6, pages 1126-1130, DOI:10.1016/j.urology.2004.12.058. [PDF]
  • Barr H, Stone N, Rembacken B. (2005) Endoscopic therapy for Barrett's oesophagus, Gut, volume 54, no. 6, pages 875-884, DOI:10.1136/gut.2004.047118. [PDF]

2004

2003

  • Reyes-Goddard J, Woodman A, Stone N, Barr H, Creighton JA, Saito Y, Batchelder D. (2003) Surface enhanced Raman scattering of the tear film, Diagnostic Optical Spectroscopy in Biomedicine II, DOI:10.1364/ecbo.2003.5141_219.
  • Smith J, Kendall C, Christie-Brown J, Sammon A, Stone N. (2003) Raman Spectroscopy in the assessment of breast cancer and axillary lymph node metastases, Optics InfoBase Conference Papers, pages 305-309.
  • Kendall C, McCloskey K, Stone N, Barr H, Greenhalgh D. (2003) Multiphoton imaging in the detection of malignancy in the oesophagus, Optics InfoBase Conference Papers, pages 51-55.
  • Reyes-Goddard J, Woodman A, Stone N, Barr H, Creighton JA, Saito Y, Batchelder D. (2003) Surface enhanced Raman scattering of the tear film, Optics InfoBase Conference Papers, pages 219-229.
  • Kendall C, Stone N, Shepherd N, Barr H. (2003) Raman spectral mapping for the illumination of biochemical changes associated with malignancy in the oesophagus, Optics InfoBase Conference Papers, pages 237-248.
  • Crow P, Stone N, Kendall C, Uff J, Ritchie A, Wright M. (2003) Optical diagnostics in bladder cancer: the use of Raman spectroscopy to differentiate between bladder pathologies in vitro, Journal of Urology, volume 169, pages 225-225.
  • Sulé-Suso J, Zholobenko V, Stone N, El Haj A. (2003) 30 Effects of chemotherapy on lung cancer cell lines measured with Fourier transform infrared spectroscopy, Lung Cancer, volume 41, pages S281-S281.
  • Smith J, Kendall C, Christie-Brown J, Sammon A, Stonea N. (2003) Raman Spectroscopy in the assessment of breast cancer and axillary lymph node metastases, European Conference on Biomedical Optics, pages 5141\_305-5141\_305.
  • Kendall C, Stone N, Shepherd N, Barr H. (2003) Raman spectral mapping for the illumination of biochemical changes associated with malignancy in the oesophagus, European Conference on Biomedical Optics, pages 5141\_237-5141\_237.
  • Kendall C, McCloskey K, Stone N, Barr H, Greenhalgh D. (2003) Multiphoton imaging in the detection of malignancy in the oesophagus, European Conference on Biomedical Optics, pages 5139\_51-5139\_51.
  • Smith J, Stone N, Kendall C, Christie-Brown J, Shepherd N, Sammon A, Barr H. (2003) Raman spectroscopy: a novel optical technique for the diagnosis and management of carcinoma of the oesophagus and breast, and lymph node metastases, BRITISH JOURNAL OF SURGERY, volume 90, no. 5, pages 637-637. [PDF]
  • Chandratreya NV, Stone N, Kendall C, Glass RE, Barr H, Shepherd N. (2003) Near infrared Raman spectroscopy a new tool for detection and classification of colonic disease, BRITISH JOURNAL OF SURGERY, volume 90, pages 66-66. [PDF]
  • Kendall C, Stone N, Shepherd N, Barr H. (2003) Raman spectral mapping for the illumination of biochemical changes associated with malignancy in the oesophagus, Proceedings of SPIE - The International Society for Optical Engineering, volume 5141, pages 237-248, DOI:10.1117/12.500438.
  • Kendall C, McCloskey K, Stone N, Barr H, Greenhalgh D. (2003) Multiphoton imaging in the detection of malignancy in the oesophagus, Proceedings of SPIE - The International Society for Optical Engineering, volume 5139, pages 51-55, DOI:10.1117/12.500486.
  • Reyes-Goddard J, Woodman A, Stone N, Barr H, Creighton JA, Saito Y, Batchelder D. (2003) Surface enhanced Raman scattering of the tear film, Proceedings of SPIE - The International Society for Optical Engineering, volume 5141, pages 219-229, DOI:10.1117/12.500643.
  • Smith J, Kendall C, Christie-Brown J, Sammon A, Stone N. (2003) Raman spectroscopy in the assessment of breast cancer and axillary lymph node metastases, Proceedings of SPIE - The International Society for Optical Engineering, volume 5141, pages 305-309, DOI:10.1117/12.500472.
  • Crow P, Stone N, Kendall CA, Persad RA, Wright MPJ. (2003) Optical diagnostics in urology: current applications and future prospects, BJU Int, volume 92, no. 4, pages 400-407, DOI:10.1046/j.1464-410x.2003.04368.x. [PDF]
  • Kendall C, Stone N, Shepherd N, Geboes K, Warren B, Bennett R, Barr H. (2003) Raman spectroscopy, a potential tool for the objective identification and classification of neoplasia in Barrett's oesophagus, J Pathol, volume 200, no. 5, pages 602-609, DOI:10.1002/path.1376. [PDF]
  • Stone N. (2003) Standardizing dosimetry in esophageal PDT: an argument for use of centering devices and removal of misleading units, Technol Cancer Res Treat, volume 2, no. 4, pages 333-338, DOI:10.1177/153303460300200408. [PDF]
  • Smith J, Kendall C, Sammon A, Christie-Brown J, Stone N. (2003) Raman spectral mapping in the assessment of axillary lymph nodes in breast cancer, Technol Cancer Res Treat, volume 2, no. 4, pages 327-332, DOI:10.1177/153303460300200407. [PDF]
  • Crow P, Stone N, Kendall CA, Uff JS, Farmer JAM, Barr H, Wright MPJ. (2003) The use of Raman spectroscopy to identify and grade prostatic adenocarcinoma in vitro, Br J Cancer, volume 89, no. 1, pages 106-108, DOI:10.1038/sj.bjc.6601059. [PDF]
  • Barr H, Kendall C, Stone N. (2003) Photodynamic therapy for esophageal cancer: a useful and realistic option, Technol Cancer Res Treat, volume 2, no. 1, pages 65-76, DOI:10.1177/153303460300200108. [PDF]

2002

2001

  • Stone N. (2001) Raman spectroscopy of biological tissue for application in optical diagnosis of malignancy.
  • Barr H, Dix AJ, Kendall C, Stone N. (2001) The potential role for photodynamic therapy in the management of upper gastrointestinal disease, Alimentary pharmacology & therapeutics, volume 15, pages 311-321, article no. 3.
  • Barr H, Dix AJ, Kendall C, Stone N. (2001) Review article: the potential role for photodynamic therapy in the management of upper gastrointestinal disease, Aliment Pharmacol Ther, volume 15, no. 3, pages 311-321, DOI:10.1046/j.1365-2036.2001.00936.x. [PDF]

2000

1999

  • Tan WC, Fulljames C, Stone N, Dix AJ, Shepherd N, Roberts DJH, Brown SB, Krasner N, Barr H. (1999) Photodynamic therapy using 5-aminolaevulinic acid for oesophageal adenocarcinoma associated with Barrett's metaplasia, Journal of Photochemistry and Photobiology B: Biology, volume 53, no. 1-3, pages 75-80, DOI:10.1016/S1011-1344(99)00129-3.
  • Fulljames C, Stone N, Bennett D, Barr H. (1999) Beyond white light endoscopy - The prospect for endoscopie optical biopsy, Italian Journal of Gastroenterology and Hepatology, volume 31, no. 8, pages 688-694.
  • Fulljames C, Stone N, Bennett D, Barr H. (1999) Beyond white light endoscopy--the prospect for endoscopic optical biopsy, Ital J Gastroenterol Hepatol, volume 31, no. 8, pages 695-704. [PDF]

1998

1996

1993

  • Marshall P, Stone N. (1993) Fibre-matrix interface transverse tensile debonding, Journal of materials science letters, volume 12, pages 218-219, article no. 4.

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Further information

Personal Homepage

I lead the Biomedical Spectroscopy team exploring the novel use of novel vibrational spectroscopic techniques for point of care testing, advanced spectral histopathology and rapid in vivo diagnostics. Here we explore the power of light to measure the changes in the molecular constituents of cells and tissues as disease develops. This can be achieved in short timescales, in a minimally invasive manner using fibre optics or deep scattering methods.

Further details of my research projects can be found at the Biomedical Imaging Research page.

Basic science, translated from bench to bedside.

I have worked for most of my career at the interface between physics, engineering and medicine. I have worked been working to pioneer the field of novel optical diagnostics within the clinical environment, working closely at the clinical/academic/commercial interface to pull-through novel technologies to be used where they have most clinical need. I have worked in multi-sectoral consortia to develop clinical tools for in vivo Raman endoscopy (RECaD), SERS diagnostics (Mesophotonics), in vivo optical coherence tomography (Michelson Diagnostics), novel infrared histopathology (MINERVA).  I was recently appointed to the position of Professor of Biomedical Imaging and Biosensing at the University of Exeter, leading me to relinquish the positions of Consultant Clinical Scientist and Head of the Biophotonics Research Unit at Gloucestershire Hospitals and Professor of Biophotonics at Cranfield University. There I established an internationally recognised research unit within a district general hospital pioneering novel optical techniques for diagnostics and therapeutics.

I currently hold the positions of Honorary Consultant Clinical Scientist at Gloucestershire Hospitals NHS Foundation Trust and at the Royal Devon and Exeter Foundation Trust.

Funded research projects

Projects for which I was the Principal or Co-Investigator:

2013-2016 EPSRC Healthcare Technology £971,955
2013-2016 EPSRC Healthcare Technology £748,432 (PI)
2012-2015 STFC Research Studentship £38,500 (PI)
2012-2015 LINC Research Studentship £60,000 (PI)
2009-2012 BCSP Research Studentship £45,000 (PI)
2012-2016 Minerva – FP7 €7.4M (€578,000)
2012-2015 NIHR i4i Raman Needle Probe £700,846 (£531,000) (PI)
2012-2015 Cobalt Professorship £105,000 (PI)
2010-2012 Royal College of Surgeons
2011 Commercial Consultancy Income £24,000
2011-2014 Gloucestershire NHS Research Fellowship (DEng) £30,000
2011-2013 McIntyre Clinical Research Fellowship £100,000
2010-2012 BUPA Foundation £96,016 (PI)
2010-2011 NIHR i4i FPD 1 Subcutaneous Raman £97,434
2010-2011 CRUK £25,000
2010-2011 Bowel Disease Research Foundation £30,000
2009-2012 NIHR Fellowship (in group) Raman molecular cancer diagnostics £139,221
2009-2012 STFC Research Studentship £45,000 (PI)
2009-2012 LINC Research Studentship £60,000 (PI)
2009-2012 BCSP Research Studentship £45,000
2007-2012 DH Career Scientist Research Fellowship (NIHR Senior Research Fellow) £452K (PI)
2007-2009 Dti OCT at 1 Micron: Improved ContRast for Optimal detection of Neoplasm (OMICRON) £ 553K (£55K)
2006-2009 IPEM Research Fellowship (PhD) £75K.
2006-2009 CPMS Pump Prime Fund PhD Studentship (Vascular OCT) £60K. (PI)
2006-2007  Cobalt Appeal Fund Research Bursary £24K (DM prostate cancer diagnostics).
2005-2008 Dti Nano-photonics SERS applications for clinical diagnosis. £2M (£175K).
2005-2009 (IN GROUP) Royal Society Dorothy Hodgkins Research Fellowship £200K.
2005 Co-applicant CCLRC ULTRA (Ultrasensitive Lifesciences Time Resolved Analysis).
2005-2006 CCLRC Rutherford Appleton Laboratory £90K.
2005 Co-applicant Framework 6: Biomedical applications of IR synchrotron radiation.
2007-2008 Cobalt Appeal Fund Research Bursary (Breast) £40K. (PI)
2005-2008 LINC Robert Dalton Research Fellowship (PhD) £60K. (PI)
2005-2008 CPMS Pump Prime Fund PhD Studentship (Lymph nodes) £60K. (PI)
2004 Cobalt Appeal Fund, £110K, Equipment funding, ‘Enhanced Pathological Diagnosis of Cancers and Pre-Cancers.’ (PI)
2004-2007 CPMS Pump Prime Fund PhD Studentship (OCT) £60K. (PI)
2004 CCLRC Rutherford Appleton Laboratory £75K. (PI)
2004-2008 Health Technology Device Funding (DoH) £ 290 K. (PI)
2004-2005 NHS Research Programme Funding £43K.
2004-2005 Cobalt Appeal Fund Research Bursary (Urology) £20K.
2004 Council for the Central Laboratory of the Research Councils (CCLRC) £18K.
2003-2004 NHS Research Programme Funding £24K.
2002 Royal College of Ophthalmologists £5K.
2002-2006 NHS R&D Postdoctoral Research Fellowship £ 180 K. (PI)
2001-2002 Research Contract, £ 27.3 K, ‘Raman Spectroscopy for Detection of Cancer in the Oesophagus.’ (PI)
2001-2002 South West Regional Development Agency Infrastructure, £29.6 K ‘Cranfield Medical Research Centre. (PI)
1998-2001 MEDLINK (DTI & Department of Health), £928 K ‘Raman Endoscope for Cancer Detection’ (in the oesophagus).
2000-2001 South West Regional Development Agency Infrastructure, £44.8 K ‘Cranfield Medical Research Centre.’
1995-1998 Winfield Research Bursary, £48 K ‘Tissue Viability Studies in the Anterior Cruciate Ligament with Optical Spectroscopy Techniques.’ (PI)
1996 Barnwood Trust Equipment Grant, £10 K ‘Tissue diagnostics with optical spectroscopy. (PI)

Facilities

CCLRC - Rutherford Appleton Laboratory / Daresbury Synchrotron / Diamond Light Source / Aladdin Light Source (Wisconsin)

Invited Presentations

Invited presentations since Jan 2008:
2008 Invited speaker Gordon Conference, Boston, USA.
2008 Invited speaker International Conference on Raman Spectroscopy, Uxbridge, UK.
2008 National Cancer Research Institute, ‘Molecular imaging without stains using Raman spectroscopy, a potential histopathological tool.’
2008 Invited speaker SPEC Brazil ‘Early Cancer Analysis and Diagnostics Using Raman Spectroscopy.’
2009 Invited speaker International Conference on Applied Vibrational Spectroscopy, Melbourne, Australia.
2009 Invited speaker Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), Louisville, Kentucky, USA
2009 Invited IPEM Managing Grants
2009 Invited BMLA Conference – Optical Diagnostics Keynote
2009 Invited Dundee opening new biomedical interface centre.
2009 Invited BC-ISMRM Cardiff
2009 Lecture European Biophotonics Summer School (Ireland)
2009 Invited NIHR Faculty Trainees Conference
2009 Invited NHS Employers
2009 Invited NHS CSO Conference
2010 Invited SMI Imaging in Oncology
2010 Invited LSF Annual Users Meeting
2010 Invited European Laser Association International Symposium, Taragona Spain.
2010 Invited Strathclyde University lecture programme.
2010 Invited Royal College of Radiologists ASM
2010 Invited Renishaw spectroscopy workshop
2010 Invited Deep Raman talk IRDG Manchester
2010 Invited speaker Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), Rayleigh, North Carolina, USA – Vibrational Spectroscopy of Lymph nodes
2010 Invited speaker Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), Rayleigh, North Carolina, USA – Blood, sweat and tears, DCDRS
2010 Invited International Cancer Colloquium – St Andrews
2011 Invited CSO Modernising Scientific Careers Higher Education Breifing Event
2011 Invited Parliamentary Science Committee
2011 Invited Healthcare Innovation EXPO Keynote speaker
2011 Invited International Conferenece on Biomaterials Science, Tsukuba, Japan (Cancelled).
2011 Invited UK Chapter of the Society for Applied Spectroscopy inaugural meeting.
2011 International Conference on Applied Vibrational Spectroscopy, Sonoma, USA.
2011 Invited iNets SW.
2011 Invited NIHR Grants workshop mentor.
2011 European Medical Physics and Engineering Conference, Dublin. 2011 – Best Oral Presentations Prize
2011 Invited KTN Network - Advances in non-invasive biosensing techniques for medical diagnostics and monitoring.
2011 Invited Nano meets spectroscopy, NPL.
2011 Invited speaker Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), Reno, Nevada, USA – SESORS.
2012 Invited Long term conditions – Effective Cancer Care, Monitoring and Treatment.
2012 Invited UK SAS FTIR London
2012 Invited speaker ICORS Bangalore.
2012 Invited Diamond Synchrotron Users Meeting
2012 Invited Renishaw Users meeting
2012 Invited speaker RSC session – SciX – St Louis
2012 Invited Aladdin Wisconsin Synchrotron Users Meeting
2012 Invited Photonex UK
2013 Invited SciX Milwaukee
2013 Invited Aladdin Wisconsin Synchrotron Users Meeting
2014 Invited Pittcon, Chicago
2014 Invited Plenary International Conference of Raman spectroscopy, Jena.
2014 Invited Plenary SPEC Shining Light on Disease, Krakow.


Contributions to the Community

Institute of Physics and Engineering in Medicine (IPEM)

Vice President (Academic) (2013- )
Chair Academic Advisory Group (2011-2014)
Council Member   (2011-2014)
Vice-Chair Academic Advisory Group (2010-2011)
Director of  Science Board (2008-2010)
Council Member / Trustee   (2008-2010)
Vice-Chair Scientific Engineering and Technology Committee (2006-2008)
Council Elected Member / Trustee   (2003-2006)
IPEM Academic Development Group. (2003-2010)
IPEM Scientific Committee (2004-2006)
IPEM Communications Working Group (2006-2007)
Society of Applied Spectroscopy (International)
Meggars Award Committee Member (2013- )
Chair Lippincott Award Committee (2013- )

RSC Analyst Editorial Advisory Board (2013- )
British Standards Institute Non-Ionising Radiation Safety Committee(EPL/76). (2003-2009)

British Medical Laser Association Executive. (2002- )
Head and Neck Optical Diagnostics Society Council Member (2008-   )

Diagnostic Application of Synchrotron Infrared Microscopy (DASIM) Executive (EU Framework 6 Programme) (2006-2008)
STFC Biomedical Network Member

Review panel for Soleil Synchrotron (2009-  )


Conference Organisation since 2008

2008 Programme Committee and Session Chair for Advanced Laser Technologies Focused on Biomedical Optics, SPIE.
2008 Programme committee for SPEC 2008 Brazil.
2008 Organising Committee for Institute of Physics and Engineering in Medicine Annual Scientific Conference, Bath.
2009 Organising Committee for Institute of Physics and Engineering in Medicine MPEC, Liverpool.
2010 Chair of Session and Member of Programme Committee for International Conference on Biomedical Vibrational Spectroscopy, BiOS 2010, SPIE, San Francisco, USA.
2010 Co-Chair of SPEC 2010 Manchester.
2010 Organising Committee for Institute of Physics and Engineering in Medicine MPEC, Nottingham.
2011 Section Chair (5 half day sessions) for Biomedical and Bioanalytical Spectroscopy at FACSS, Reno.
2011 Section Co-chair British Medical Laser Association Photodiagnostics and OCT Session organizer and chair.
2011 Session Chair and International Committee for European Medical Physics and Engineering Conference, Dublin.
2012 Chair of Session and Member of Programme Committee for International Conference on Biomedical Vibrational Spectroscopy, BiOS 2010, SPIE, San Francisco, USA.
2012 International Advisory Board. SPEC Shedding Light on Disease, Thailand.
2012 Programme Committee Photonex.
2013 British Medical Laser Association Scientific Committee, Annual meeting, Manchester.
2014 International Advisory Board. SPEC Shedding Light on Disease, Krakow.


Memberships

  • Fellow of the Institution of Physics and Engineering in Medicine (IPEM).
  • Member of the Society for Applied Spectroscopy.
  • Registered Clinical Scientist [CS 3557]
  • Chartered Scientist [PEM 108 002563]
  • Fellow of the Head and Neck Optical Diagnostic Society
  • Member of the British Medical Laser Association.
  • Member of the Coblentz Society.


Prizes Since 2008:

2009 The Chief Scientific Officers National R&D Award.
2010 Extraordinary Scientists – Top 100 Scientists in Health.
2011 European Medical Physics and Engineering Conference – Presidents’s Prize for Best Oral Presentation.
2012 FACSS/SAS/Coblentz/ISA Award at ICORS 2012 in Bangalore.
2013 Highly Commended NHS Innovation Challenge Prizes - Earlier Cancer Diagnosis and Improving Diagnostic Investigation.

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