Overview
I’m a dedicated researcher passionate about unraveling the complexities of embryogenesis in mammals. With a robust background in Mathematics, Physics, Computer Science, Biophysics and Engineering I am a Postdoctoral Research Fellow at the Living Systems Institute, in Dr David Richards group. My journey in academia has led me to focus on using mathematical modelling and computer simulation to study the earliest stages of mammalian embryo development. This exciting project aims to dissect the rules governing embryo development from a single cell to the mature blastocyst. Beyond my intrinsic interest in embryology, my research holds the potential for transformative impacts on human fertility treatments and understanding. I bring a rich skill set in high-level mathematical and computational skills, including programming in languages such as C++, MATLAB, and Python, complemented by a track record of high-quality research outputs. My work is motivated by a deep-seated belief in the power of interdisciplinary research to solve complex biological questions, bridging the gap between biology, physics, mathematics, and medicine. Here, you’ll find insights into my research endeavors, publications, and the journey I’m on to contribute meaningful advances in our understanding of life’s earliest stages. Thank you for joining me on this exciting journey!
I also work on phagocytosis, and I developed a mathematical model to simulate the engulfment stage of phagocytosis and investigate the effect of cell and target shapes and positions during this process. Phagocytosis transports large solid particles into the cell by engulfing them. Because large particles are difficult to engulf, phagocytosis must be an active process. Elie Metchnikoff first observed this process in starfish larvae in 1882 and is often taken as the birth of modern immunology. Engulfment via phagocytosis is essential both in our immune systems (to remove bacteria and dead cells) and in some single-celled organisms (such as Dictyostelium) as a way of acquiring nutrients. Due to its critical role in both health and disease, understanding phagocytosis is of vital importance.
Publications:
Giuraniuc, C. V., Parkin, C., Almeida, M. C., Fricker, M., Shadmani, P., Nye, S., ... & Brand, A. C. (2023). Dynamic calcium-mediated stress response and recovery signatures in the fungal pathogen, Candida albicans. Mbio, 14(5), e01157-23.
Shadmani, P., Mehrafrooz, B., Montazeri, A., & Naghdabadi, R. (2019). Protein corona impact on nanoparticle-cell interactions: toward an energy-based model of endocytosis. Journal of Physics: Condensed Matter, 32(11), 115101.
Shadmani, P., Montazeri, A., Taherifar, N., & Motevalli, B. (2017). Telescopic oscillations of double-walled carbon nanotubes in the presence of an inner semi-infinite tube. International Journal of Mechanical Sciences, 121, 187-198.
Mohebali, M., Rezapour, N., Shadmani, P., & Montazeri, A. (2020). An MD-based systematic study on the mechanical characteristics of a novel hybrid CNT/graphene drug carrier. Journal of Molecular Modeling, 26(9), 1-12.
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