Profile
Mr Peyman Shadmani
Research assistant, PhD Student
Telephone: 01392 727464
Extension: (Streatham) 7464
I am a PhD student working under the supervision of Dr David Richards, and Dr Kirsty Wan. In this PhD, a mathematical model will be developed to simulate the cell and target shapes and positions during the engulfment of foreign particles via phagocytosis.
Phagocytosis transports large solid particles into the cell by engulfing them. Because large particles are difficult to engulf, phagocytosis must be an active process. Elie Metchnikoff first observed this process in starfish larvae in 1882 and is often taken as the birth of modern immunology. Engulfment via phagocytosis is essential both in our immune systems (to remove bacteria and dead cells) and in some single-celled organisms (such as Dictyostelium) as a way of acquiring nutrients. Due to its critical role in both health and disease, understanding phagocytosis is of vital importance.
Publications:
Shadmani, P., Mehrafrooz, B., Montazeri, A., & Naghdabadi, R. (2019). Protein corona impact on nanoparticle-cell interactions: toward an energy-based model of endocytosis. Journal of Physics: Condensed Matter, 32(11), 115101.
Shadmani, P., Montazeri, A., Taherifar, N., & Motevalli, B. (2017). Telescopic oscillations of double-walled carbon nanotubes in the presence of an inner semi-infinite tube. International Journal of Mechanical Sciences, 121, 187-198.
Mohebali, M., Rezapour, N., Shadmani, P., & Montazeri, A. (2020). An MD-based systematic study on the mechanical characteristics of a novel hybrid CNT/graphene drug carrier. Journal of Molecular Modeling, 26(9), 1-12.
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